Synergistic Effects of Helicobacter pylori Outer Inflammatory Protein A (oipA) and cag Pathogenicity Island (cag PAI) on Interleukin-1β and Interleukin-8 Gene Expression Levels in Gastric Tissues of Thai Gastroduodenal Patients
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چکیده
منابع مشابه
Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori.
RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown. We cocultured gastric epithelial cells with wild-type H. pylori, isogenic oipA mutants, cag pathogenicity island (PAI) mutants, or double knockout mutants. Reverse transcr...
متن کاملStructure of cag pathogenicity island in Japanese Helicobacter pylori isolates.
BACKGROUND cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. AIM To characterise cagA and the cag PAI in Japanese H pylori strains. METHODS H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from...
متن کاملModulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue.
BACKGROUND Strains of Helicobacter pylori carrying the virulence associated cag pathogenicity island (PAI) induce gastric epithelial synthesis of the chemokine interleukin-8 (IL-8), a neutrophil chemoattractant, and thereby a strong inflammatory response during chronic infection of the human gastric mucosa. Previous mutational analyses have shown that many genes in the cag PAI are needed to eli...
متن کاملPapers Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue
Background—Strains of Helicobacter pylori carrying the virulence associated cag pathogenicity island (PAI) induce gastric epithelial synthesis of the chemokine interleukin-8 (IL-8), a neutrophil chemoattractant, and thereby a strong inflammatory response during chronic infection of the human gastric mucosa. Previous mutational analyses have shown that many genes in the cag PAI are needed to eli...
متن کاملCorrelation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease.
Helicobacter pylori infection is associated with a variety of outcomes ranging from seemingly asymptomatic coexistence to peptic ulcer disease and gastric cancer. The cag pathogenicity island (PAI) contains genes associated with a more aggressive phenotype and has been suggested to be a determinant of severe disease outcome. The cagA gene has served as a marker for the cag PAI. However, the pre...
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ژورنال
عنوان ژورنال: Journal of Pure and Applied Microbiology
سال: 2018
ISSN: 0973-7510
DOI: 10.22207/jpam.12.2.03